High-level treatment recommendations published by the American College of Cardiology and the American Heart Association, which were supported by multiple randomized controlled trials, have proved to be the most “durable” and least likely to change over time.

In a study published in JAMA, Penn Medicine researchers analyzed changes over time in more than 600 Class I ACC/AHA recommendations, each of which recommended strongly in favor of a particular treatment or procedure related to cardiovascular disease.

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