A multi-institution analysis of the records of two large cohorts has concluded sepsis may contribute to half of all hospital deaths, according to a study presented at the annual conference of the American Thoracic Society.

The researchers quantified the contribution of sepsis to mortality in two complementary inpatient cohorts from Kaiser Permanente Northern California (KPNC) and the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. The KPNC cohort included 482 828 adults with overnight, nonobstetrical hospitalizations at 21 KPNC hospitals between 2010 and 2012, and the NIS, a nationally representative sample of 1051 hospitals, included 6.5 million unweighted adult hospitalizations in 2010.

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