Pediatric Cancer Genome Data Open to Researchers

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Two years ago, St. Jude Children’s Hospital and Washington University School of Medicine started the Pediatric Cancer Genome Project to sequence the entire genomes of normal and cancer cells of 600 pediatric cancer patients over three years.

Sequencing a complete pediatric cancer genome had not been accomplished before the project started, according to the organizations. Now with more than 250 sets sequenced, the organizations have launched a Web site to share data and discoveries with other researchers.

The launch comes shortly after publication in Nature of two discoveries from the project, including better understanding of an aggressive type of acute lymphoblastic leukemia.

The new Web site, called Explore, is designed for use by clinical and basic researchers and will include genomic data and data visualizations, an overview of the genome project’s progress, and access to specific disease information, summaries of current discoveries, links to publications and views of single-patient genome data to disease levels. The database is available at

The articles in the January 2012 issue of Nature are “A novel retinoblastoma therapy from genomic and epigenetic analyses,” and “The genetic basis of early T-cell precursor acute lymphoblastic leukaemia."

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