Medical device company CareFusion Corp. has introduced a software algorithm to automatically control the oxygen level in newborns needing mechanical ventilation.

The Closed Loop Controller of Inspired Oxygen system, or CLiO2T, is an enhancement to the San Diego-based company's AVEAT ventilator. The system processes blood oxygen saturation levels using a computer algorithm that anticipates trends and modifies the amount of oxygen delivered, second-by-second if necessary. Oxygen levels that are too high or low can cause lung and vision damage in premature babies, says Steven Donn, M.D., a professor of pediatrics at the University of Michigan Health System, which was a clinical trials site.

The CLiO2 system has not yet received Food and Drug Administration approval. It is currently available in parts of Western Europe and Asia. More information is available at

--Joseph Goedert


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