As the ever-present goal of improved clinical care and reduced costs continues to loom, the healthcare industry has focused in on population health -- an approach that specifically aims to improve the health of entire human populations. A report published in the Journal of the American Medical Association in 2013 provides some good news and bad news regarding the success of such population health efforts. According to the study, overall population health in the United States has been improving yet improvements have not kept pace with population health advances in other wealthy countries and illness and chronic disability now account for nearly half of the health burden in the U.S. To improve population health efforts, healthcare organizations are beginning to turn to a variety of information technology applications. This supplement looks at the challenges and opportunities facing healthcare organizations that are seeking to leverage information technology to better their population health efforts. Read on to find out more.