A multi-institutional team of scientists led by Johns Hopkins cardiologist and biomedical engineer Hiroshi Ashikaga, M.D., has developed a mathematical model to measure and digitally map the beat-sustaining electrical flow between heart cells.

The work, the scientists say, could form a blueprint for vastly more precise imaging tests that capture cell-to-cell communication and pinpoint the clusters of cells at the epicenter of complex, life-threatening arrhythmias. Such imaging approaches would enable precision-targeted, minimally invasive treatments that eliminate rhythm-disrupting hotspots in the heart’s electrical system.

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